Vardenafil Dosage How much to take for the first time ?

Applies to the following strengths: 2.5 mg; 5 mg; 10 mg; 20 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

  • Erectile Dysfunction

Usual Geriatric Dose for:

  • Erectile Dysfunction

Usual Adult Dose for Erectile Dysfunction

-Initial dose: 10 mg orally once a day, as needed, approximately 60 minutes before sexual activity. Increase to 20 mg or decrease to 5 mg based on efficacy and tolerability.
-Maximum dose: 20 mg once a day

Patients on stable alpha blocker therapy:
-Initial dose: 5 mg orally once a day

Comments:
-Sexual stimulation is required for a response to treatment.
-A time interval between dosing should be considered when administering this drug concomitantly with alpha-blockers.
-Patients taking alpha-blockers should not initiate vardenafil therapy with the orally disintegrating tablet.

Use: Erectile dysfunction

Usual Geriatric Dose for Erectile Dysfunction

65 years or older:
-Initial dose: 5 mg orally once a day, as needed, approximately 60 minutes before sexual activity

Comments: Sexual stimulation is required for a response to treatment.

Use: Erectile dysfunction

Renal Dose Adjustments

-CrCl: 30 to 80 mL/min: No adjustment recommended.

Comment: The orally disintegrating tablet (brand Staxyn) can be used in patients with mild, moderate or severe renal impairment.

Liver Dose Adjustments

-Mild hepatic dysfunction (Child-Pugh A): No adjustment recommended.
-Moderate hepatic dysfunction (Child-Pugh B): 5 mg orally once a day, as needed, approximately 60 minutes before sexual activity. The maximum dose should not exceed 10 mg.
-Severe hepatic dysfunction (Child-Pugh C): Use should be avoided.

Comment: The orally disintegrating tablets should not be used in patients with moderate (Child-Pugh B) or severe (Child-Pugh C) hepatic dysfunction.

Dose Adjustments

The dose may be increased to a maximum recommended dose of 20 mg or decreased to 5 mg based on efficacy and side effects.

If taking potent or moderate inhibitors of CYP450 3A4, the dose should be adjusted as follows:
-Ritonavir: No more than 2.5 mg in a 72-hour period
-Indinavir, saquinavir, atazanavir, ketoconazole 400 mg daily, itraconazole 400 mg daily, clarithromycin: No more than 2.5 mg in a 24-hour period
-Ketoconazole 200 mg daily, itraconazole 200 mg daily, erythromycin: No more than 5 mg in a 24-hour period

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